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What Is The Role Of IgG In Immune Response?

Each cell, protein, vitamin and nutrient in the body plays a role in how well the immune system functions, as well as the way it regulates and maintains its power to fight off harmful pathogens. Key cells and proteins that work together within the immune system include cytokines, lymphocytes, neutrophils, macrophages, complement proteins, and antibodies.

Antibodies, in particular, have special roles to play when it comes to your immunity. There are five in total, each serving a specific purpose. IgM antibodies, for example, are produced to hunt pathogens and mark them for destruction. The IgE antibody was recently found to have a role in allergies and the response of the immune system when an allergen enters the system. Certain lymphocytes called B cells rely on IgD to help produce new antibodies, and IgA is found in serum, nasal discharge, saliva, and breast milk and plays a role in maternal immunity, among other things.

The most prevalent antibody, however, is IgG. It makes up over 70% of all antibodies found in the system and is the only one that can pass through placenta, essentially protecting newborns in the womb and for a week after birth. It protects the body as a whole after being transported to blood and tissue. But what is the role of IgG in immune response, exactly?

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Is Mast Cell Activation Syndrome (MCAS) The Same As Mastocytosis?

Those who have severe allergies know all too well just how scary it can be to experience the symptoms of anaphylaxis. People at risk of this are constantly aware of their surroundings because just one thing can set off an attack. Although there are treatment options available for those who have both mild and severe allergies, it can still put a strain on daily living.

In some cases, anaphylaxis can happen to a person without them having an allergy at all. This type of condition is driven by the overaction of mast cells within the body. Mast cells are immune cells that release a substance called a mediator, which induces inflammation to help the body heal from an injury or infection. This condition is known as mast cell activation syndrome (MCAS). But what is MCAS, exactly? And is MCAS the same as mastocytosis?

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