mRNA vaccines

Are mRNA Vaccines Safe For Those With Mast Cell Activation Syndrome (MCAS)?

The COVID-19 virus began its sweep of the globe over a year ago, and people have been subject to its grave effects far and wide in the months that followed. At the time of writing, the virus has claimed over two and half million lives – and for the ~70 million people who have contracted the virus and survived, the negative health repercussions are still hitting hard.  

In December of 2020, some hope was given to people all over the world when the first person received the Pfizer vaccine in the UK. Since then, more vaccines have been developed and now, almost 100 million people are fully vaccinated against COVID. The vaccine rollout has been a huge relief for everyone who’s ready to return to normal life and reduce their COVID-19 risk. But is the first COVID-19 vaccine safe for everyone? More specifically, are mRNA vaccines safe for those with Mast Cell Activation Syndrome (MCAS)? Let’s find out.

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Infectolab - tick on leaf

Can Lyme Disease Cause Mast Cell Activation Syndrome (MCAS)?

Mast cell activation syndrome, or MCAS for short, is a disorder that occurs when mast cells release too much of their mediator substances at incorrect times. Mast cells are part of the immune system and are found in blood vessels throughout the body and in bone marrow. The mechanism behind MCAS is largely unknown, which is why it is often referred to as an idiopathic condition. Some research has found that a large majority of those with MCAS also have a relative with the condition, so it’s postulated that it could be linked to genetics.

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Infectolab - mold spore

3 Ways Mold Can Influence Immune Response

Mold is a type of fungi that can be found both indoors and outdoors. When the spores make their way into the air, they can be ingested. For some people, inhaling mold spores won’t elicit any sort of response. It’s unclear why mold affects some more than others, but those living with a weakened immune system, respiratory illness, allergies, or asthma can all experience negative health effects from exposure to mold spores.

The health effects caused by mold growth occur because of the organic compounds it releases into the air, including allergens, irritants and mycotoxins. In areas where excessive moisture and dampness is an issue, the number of irritants released through an overgrowth of mold can increase, leading to further exposure and possible side effects.

So, what are the ways mold can influence immune response? Immune function is compromised by overexposure to mold in several ways:

  • The disruption of proper cytokine production
  • Mast cell activation
  • Eliciting an allergic reaction within the body, leading to further illness
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